Quotes & Sayings About Ribosomes

Ribosomes contain RNA, messenger RNA provides the information, transfer RNAs brings the amino acids; so the protein-making machinery is an RNA machinery, completely. — Christian De Duve

When I started reading the literature of molecular biology, I was stunned by certain descriptions. Admittedly, I was on the lookout for anything unusual, as my investigation had led me to consider that DNA and its cellular machinery truly were an extremely sophisticated technology of cosmic origin. But as I pored over thousands of pages of biological texts, I discovered a world of science fiction that seemed to confirm my hypothesis. Proteins and enzymes were described as 'miniature robots,' ribosomes were 'molecular computers,' cells were 'factories,' DNA itself was a 'text,' a 'program,' a 'language,' or 'data.' One only had to do a literal reading of contemporary biology to reach shattering conclusions; yet most authors display a total lack of astonishment and seem to consider that life is merely 'a normal physiochemical phenomenon. — Jeremy Narby

I started working on ribosomes when I was a post doc, in 1978, when it would have been impossible, really, to solve it. But, it was just a fundamental problem in biology. — Venkatraman Ramakrishnan

Well, the human genome has massive redundancy - that means that two per cent of the DNA does all the work of instructing the ribosomes that build the proteins that make up the cells of your body. Ninety-eight per cent of your DNA just sits there doing nothing. Taking up space in the gene. — Ian McDonald

I wanted to reveal how genetic code is translated into protein. I knew a great application could be for antibiotics, since half of the useful ones target the ribosomes, but I didn't believe I could contribute to it. It was like the next Mount Everest to conquer. It was my dream to contribute something to humanity. — Ada Yonath

mitochondria and the ribosomes and the chloroplasts and the endoplasmic reticulum. — Belle Payton

Many ribosomes act simultaneously along the mRNA, forming superstructures called polysomes. — Ada Yonath

I began studying ribosomes as a postdoctoral fellow in Peter Moore's laboratory in 1978. — Venkatraman Ramakrishnan

Ribosomes have an error rate of about one letter in 10,000, far lower than the defect rate in our own high-quality manufacturing processes. And they operate at a rate of about 10 amino acids per second, building whole proteins with chains comprising hundreds of amino acids in less than a minute. — Nick Lane

I used ribosomes from very, very robust bacteria under very, very active conditions and found a way - I actually took advantage of research done before me at the Weizmann, the same institute I am now - how to preserve their activity and their integrity while they crystallized. — Ada Yonath

When the genetic code was solved, in the early 1960s, it turned out to be full of redundancy. Much of the mapping from nucleotides to amino acids seemed arbitrary - not as neatly patterned as any of Gamow's proposals. Some amino acids correspond to just one codon, others to two, four, or six. Particles called ribosomes ratchet along the RNA strand and translate it, three bases at a time. Some codons are redundant; some actually serve as start signals and stop signals. The redundancy serves exactly the purpose that an information theorist would expect. It provides tolerance for errors. Noise affects biological messages like any other. Errors in DNA - misprints - are mutations. — James Gleick