Histones Quotes & Sayings

The Portrait of a Lady is entirely successful in giving one the sense of having met somebody far too radiantly good for this world. — Rebecca West

In this model, there is a vicious cycle of events that results in the generation of a more and more repressed state. One of the predictions from this model is that repressive histone modifications attract DNA methyltransferases, which deposit DNA methylation near those histones. This methylation in turn attracts more repressive histone modifying enzymes, creating a self-perpetuating cycle that leads to an increasingly hostile region for gene expression. Experimental data suggest that in many cases this model seems to be right. Repressive histone modifications can act as the bait to attract DNA methylation to the promoter of a tumour suppressor gene. A key example of this is an epigenetic enzyme we met in the previous chapter, called EZH2. The EZH2 protein adds methyl groups to the lysine amino acid at position 27 on histone H3. This amino acid is known as H3K27. K is the single letter code for lysine (L is the code for a different amino acid called leucine). — Nessa Carey

There's one good thing about making mistakes.' Thea turned to her with a smile. 'You learn not to make them again. — Amanda Hocking

If we use common words on a great occasion, they are the more striking, because they are felt at once to have a particular meaning, like old banners, or everyday clothes, hung up in a sacred place. — George Eliot

Praying
It doesn't have to be
the blue iris, it could be
weeds in a vacant lot, or a few
small stones; just
pay attention, then patch
a few words together and don't try
to make them elaborate, this isn't
a contest but the doorway
into thanks, and a silence in which
another voice may speak. — Mary Oliver

He too had plans... he wasn't embarrassed by the idea of carefully thinking through what would be necessary to achieve them. You made a picture of the life you wanted to have, and then you worked back from there to the present. — Francis Spufford

When one has not had a good father, one must create one. — Friedrich Nietzsche

In many ways, each of us is the sum total of what our ancestors were. The virtues they had may be our virtues, their strengths our strengths, and, in a way, their challenges could be our challenges. — James E. Faust

Nothing is more disgraceful than that an old man should have nothing to show to prove that he has lived long, except his years. — Seneca The Younger

There is increasing evidence that at least some of the targeting of epigenetic modifications can be explained by interactions with long ncRNAs. Jeannie Lee and her colleagues have recently investigated long ncRNAs that bind to a complex of proteins. The complex is called PRC2 and it generates repressive modifications on histones. PRC2 contains a number of proteins, and the one that interacts with the long ncRNAs is probably EZH2. The researchers found that the PRC2 complex bound to literally thousands of different long ncRNA molecules in embryonic stem cells from mice13. These long ncRNAs may act as bait. They can stay tethered to the specific region of the genome where they are produced, and then attract repressive enzymes to shut off gene expression. This happens because the repressive enzyme complexes contain proteins like EZH2 that are capable of binding to RNA. — Nessa Carey

I don't really do jolly. I don't know why, I just don't. — Susan Hill

Bjorn Borg looks like a hunchbacked, jut-bottomed version of Lizabeth Scott, impersonating a bearded Apache princess. — Clive James