Histone Code Quotes & Sayings

In this model, there is a vicious cycle of events that results in the generation of a more and more repressed state. One of the predictions from this model is that repressive histone modifications attract DNA methyltransferases, which deposit DNA methylation near those histones. This methylation in turn attracts more repressive histone modifying enzymes, creating a self-perpetuating cycle that leads to an increasingly hostile region for gene expression. Experimental data suggest that in many cases this model seems to be right. Repressive histone modifications can act as the bait to attract DNA methylation to the promoter of a tumour suppressor gene. A key example of this is an epigenetic enzyme we met in the previous chapter, called EZH2. The EZH2 protein adds methyl groups to the lysine amino acid at position 27 on histone H3. This amino acid is known as H3K27. K is the single letter code for lysine (L is the code for a different amino acid called leucine). — Nessa Carey

As a child. I grew up on a small farm, so I did a lot of drawings of animals, chickens and people. At the bottom of every page, I'd put a strange scribble. I was emulating adult handwriting, though I didn't actually know how to write. — Joyce Carol Oates

Occurred to him that no one who hadn't been in battle could know what things were worth. — Chris Cleave

Big things are accomplished when we master the little things. — John Wooden

:No one runs from anything quite like they run from change.: — Mercedes Lackey

Gardens don't grow by themselves; they need to be tended and cultivated and weeded. The same is true of a marriage. — Billy Graham

There are a lot of things that I really question - the legality of the drone strikes, these NSA revelations. Jimmy Carter came out and said we don't live in a democracy. That's a little intense when an ex-president says that. So you know, he's got some explaining to do, particularly for a constitutional law professor. — Matt Damon

I looked at our hands, caked and coated in red, but entwined. The pristine moment when they were clasped like that earlier in the day seemed weeks ago.
"Clean." Peter said.
"Can I get a water bottle or something to clean his hands?" I scanned the crowd. He drew my attention back to him with a pull of my hand.
"No," Peter said. "I'm ... clean."
I had missed who Peter was until that very moment.
I had called him names and treated him callously. I had read every micro expression in a vacuum of how it related to Austin Glass. And in return Peter had cared for my wounds, treated me tenderly and assured me that he was HIV negative while bleeding out in a hallway of strangers.
I broke. It wasn't a visible fracture. I didn't sob or explode into anguish. I didn't give in to my vomitus urge that came from the burst of self-loathing. But I shattered nonetheless. — Dani Alexander

Once I had kids, my whole attitude changed. I was like, "You make a spinal cord from scratch and we'll talk." — Pat Benatar

He rolled her to her back and used his hands, mouth, and tongue on her, all over her, and she was greedy for that too. Arching against him, her hands coaxing and demanding, her nails scraping or diving into his hair to hold him to her. — Kristen Ashley

You must not end your life because you failed an examination. Failing an examination or making a mistake does not make you a failure at life. The context of life is broader than that. — Archibald Marwizi

It is idle to complain that a society is infringing a moral code intended to make people behave like St. Francis of Assisi if the society retorts that it does not wish to behave like St. Francis, and considers it more natural and right to behave like the Emperor Caligula. When there is a genuine conflict of opinion, it is necessary to go behind the moral code and appeal to the natural law - to prove, that is, at the bar of experience, that St. Francis does in fact enjoy a freer truth to essential human nature than Caligula, and that a society of Caligulas is more likely to end in catastrophe than a society of Franciscans. — Dorothy L. Sayers

You don't seriously believe everybody on the planet should do whatever they want, do you? That would be terrible. These people need help and guidance. — Michael Crichton

I am not talking to you from the point of view of just wishful thinking, or imaginary craziness. I'm talking to you from a deeper basic understanding - quantum physics really begins to point to this discovery, it says that you can't have a universe without mind entering into it, the mind is actually shaping the very thing that is being perceived. — Fred Alan Wolf

I've found that child's play -stuff that was not considered serious, but goofy- was the stuff I liked to do, so I still do it as an adult. — Matt Groening

My faith tells me that God does want people to understand climate change and do something about it. — Katharine Hayhoe