Ezh2 Quotes & Sayings

David and his followers taught no new doctrines, in their dispersion or when they came to power, that can be brought to countenance thee at all in shaving off thy beard. — Lord George Gordon

We look at some people as if they were special, gifted, divine. Nobody is special and gifted and divine.
No more than you are, no more than I am. The only difference, the very only one,
is that they have begun to understand what they really are and have begun to practice it. — Richard Bach

In this model, there is a vicious cycle of events that results in the generation of a more and more repressed state. One of the predictions from this model is that repressive histone modifications attract DNA methyltransferases, which deposit DNA methylation near those histones. This methylation in turn attracts more repressive histone modifying enzymes, creating a self-perpetuating cycle that leads to an increasingly hostile region for gene expression. Experimental data suggest that in many cases this model seems to be right. Repressive histone modifications can act as the bait to attract DNA methylation to the promoter of a tumour suppressor gene. A key example of this is an epigenetic enzyme we met in the previous chapter, called EZH2. The EZH2 protein adds methyl groups to the lysine amino acid at position 27 on histone H3. This amino acid is known as H3K27. K is the single letter code for lysine (L is the code for a different amino acid called leucine). — Nessa Carey

... what kind of life do we live if we let fear break us down? The truth is there will be tough times, we've certainly been through them before; but good things happen everyday. Great things. We just have to open our eyes and see them. — Christene Houston

A where's honest — Stacia Kane

There is increasing evidence that at least some of the targeting of epigenetic modifications can be explained by interactions with long ncRNAs. Jeannie Lee and her colleagues have recently investigated long ncRNAs that bind to a complex of proteins. The complex is called PRC2 and it generates repressive modifications on histones. PRC2 contains a number of proteins, and the one that interacts with the long ncRNAs is probably EZH2. The researchers found that the PRC2 complex bound to literally thousands of different long ncRNA molecules in embryonic stem cells from mice13. These long ncRNAs may act as bait. They can stay tethered to the specific region of the genome where they are produced, and then attract repressive enzymes to shut off gene expression. This happens because the repressive enzyme complexes contain proteins like EZH2 that are capable of binding to RNA. — Nessa Carey

Eugene Peterson points out that "the root meaning in Hebrew of salvation is to be broad, to become spacious, to enlarge. It carries the sense of deliverance from an existence that has become compressed, confined and cramped." God wants to set free, to make it possible for us to live open and loving lives with God and our neighbors. "I run in the path of your commands, for you have set my heart free," wrote the psalmist. — Philip Yancey