Nessa Carey Quotes
In This Model, There Is A Vicious Cycle Of Events That Results In The Generation Of A More And More Repressed State. One Of The Predictions From This Model Is That Repressive Histone Modifications Attract DNA Methyltransferases, Which Deposit DNA Methylation Near Those Histones. This Methylation In Turn Attracts More Repressive Histone Modifying Enzymes, Creating A Self-perpetuating Cycle That Leads To An Increasingly Hostile Region For Gene Expression. Experimental Data Suggest That In Many Cases This Model Seems To Be Right. Repressive Histone Modifications Can Act As The Bait To Attract DNA Methylation To The Promoter Of A Tumour Suppressor Gene. A Key Example Of This Is An Epigenetic Enzyme We Met In The Previous Chapter, Called EZH2. The EZH2 Protein Adds Methyl Groups To The Lysine Amino Acid At Position 27 On Histone H3. This Amino Acid Is Known As H3K27. K Is The Single Letter Code For Lysine (L Is The Code For A Different Amino Acid Called Leucine).
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